Stiff Person Syndrome is a rare autoimmune disorder associated with antibodies against glutamic acid decarboxylase, the key enzyme in γ -aminobutyric acid synthesis. In order to investigate the role of cerebral benzodiazepinereceptor binding in SPS, we performed [ 11 C]flumazenil positron emission tomography in a female patient with SPS compared to nine healthy controls. FMZ is a radioligand to the postsynaptic central benzodiazepine receptor which is co-localized with the GABA-A receptor. In the SPS patient, we found a global reduction of (...) cortical FMZ binding. In addition, distinct local clusters of reduced radiotracer binding were observed. These data provide first in vivo evidence for a reduced postsynaptic GABA-A receptor availability which may reflect the loss of GABAergic neuronal inhibition in SPS. (shrink)

Mohanty, J.N. Understanding Husserl's transcendental phenomenology.--Fink, E. The problem of the phenomenology of Edmund Husserl. Operative concepts in Husserl's phenomenology.--Funke, G. A transcendental-phenomenological investigation concerning universal idealism, intentional analysis, and the genesis of habitus: archē, phansis, hexis, logos.--Pentzopoulou-Valalas, T. Reflections on the foundation of the relation between the a priori and the eidos in the phenomenology of Husserl.--Landgrebe, L. Regions of being and regional ontologies in Husserl's phenomenology. The problem posed by the transcendental science of the a priori of (...) the life world.--Wahl, J. Notes on the first part of Experience and judgment by Husserl.--Landgrebe, L. A letter from Ludwig Landgrebe to Jean Wahl.-- Wahl, J. A note on some empiricist aspects of the thought of Husserl.--Toulemont, R. The specific character of the social according to Husserl. (shrink)

This collection of essays by leading international philosophers considers central themes in the ethics of Danish philosopher Knud Ejler Løgstrup (1905–1981). Løgstrup was a Lutheran theologian much influenced by phenomenology and by strong currents in Danish culture, to which he himself made important contributions. The essays in What Is Ethically Demanded? K. E. Løgstrup’s Philosophy of Moral Life are divided into four sections. The first section deals predominantly with Løgstrup’s relation to Kant and, through Kant, the system of morality in (...) general. The second section focuses on how Løgstrup stands in connection with Kierkegaard, Heidegger, and Levinas. The third section considers issues in the development of Løgstrup’s ethics and how it relates to other aspects of his thought. The final section covers certain central themes in Løgstrup’s position, particularly his claims about trust and the unfulfillability of the ethical demand. The volume includes a previously untranslated early essay by Løgstrup, “The Anthropology of Kant’s Ethics,” which defines some of his basic ethical ideas in opposition to Kant’s. The book will appeal to philosophers and theologians with an interest in ethics and the history of philosophy. (shrink)

This Companion provides a fresh and comprehensive account of this outstanding work, which remains among the most frequently read works of Greek philosophy, indeed of Classical antiquity in general. The sixteen essays, by authors who represent various academic disciplines, bring a spectrum of interpretive approaches to bear in order to aid the understanding of a wide-ranging audience, from first-time readers of the Republic who require guidance, to more experienced readers who wish to explore contemporary currents in the work’s interpretation. The (...) three initial chapters address aspects of the work as a whole. They are followed by essays that match closely the sequence in which topics are presented in the ten books of the Republic. Since the Republic returns frequently to the same topics by different routes, so do the authors of this volume, who provide the readers with divergent yet complementary perspectives by which to appreciate the Republic’s principal concerns. (shrink)

The purpose of this study is to determine the relative frequency of course offerings on social issues and business ethics in American business schools. Specifically, a random sample of the curricula of 119 American business schools were analyzed in order to gauge the importance given to coursework on ethics and social issues. The findings indicated that the incidence of such courses was generally low in American business curricula, particularly at the graduate level. These findings are discussed in light of the (...) current concern for more responsible corporate behavior. (shrink)

Tracing a central theme of Plato's Republic , G. R. F. Ferrari reconsiders in this study the nature and purpose of the comparison between the structure of society and that of the individual soul. In four chapters, Ferrari examines the personalities and social status of the brothers Glaucon and Adeimantus, Plato's notion of justice, coherence in Plato's description of the decline of states, and the tyrant and the philosopher king—a pair who, in their different ways, break with the terms of (...) the city-soul analogy. In addition to acknowledging familiar themes in the interpretation of the Republic —the sincerity of its utopianism, the justice of the philosopher's return to the Cave—Ferrari provocatively engages secondary literature by Leo Strauss, Bernard Williams, and Jonathan Lear. With admirable clarity and insight, Ferrari conveys the relation between the city and the soul and the choice between tyranny and philosophy. City and Soul in Plato's Republic will be of value to students of classics, philosophy, and political theory alike. (shrink)

This full-length study of Plato's dialogue Phaedrus, now in paperback, is written in the belief that such concerted scrutiny of a single dialogue is an important part of the project of understanding Plato so far as possible 'from the inside' - of gaining a feel for the man's philosophy. The focus of this account is on how the resources both of persuasive myth and of formal argument, for all that Plato sets them in strong contrast, nevertheless complement and reinforce each (...) other in his philosophy. Not only is the dialogue in its formal structure a dovetail of myth and argument, but the philosophic life that it praises is also shaped by an acknowledgement of the limitations of argument and the importance of mythical understanding. By means of this correlation of form and content Plato invites his readers, through the very act of reading, to take a first step along the path of the philosophical life. (shrink)

This paper discusses the surprising resurgence in the fortunes of the British eugenics movement in the 1930s. It is argued that although mass unemployment may in the long run have discredited that version of eugenics in which social dependence and destitution were attributed to genetic defect, in the short run the Depression was often perceived as a vindication of the eugenical creed. In particular, the attempt to reduce the fertility of the unemployed by popularising birth control techniques, and the voluntary (...) sterilization campaign aimed at preventing the propagation of defectives from the so-called Social Problem Group, satisfied the urge felt by many conservative members from the professional classes to respond creatively to the country's crisis, without endangering existing social and economic institutions. It is also shown that not until 1938 did events in Germany cause substantial damage to the cause of eugenics in Britain. In fact, the ‘German experiment’ was actually greeted with approval by certain British eugenists of an authoritarian cast of mind. However, the Society as a whole never identified with these right-wing extremists, thanks in part to the moderating influence exercised by its General Secretary, Dr. C. P. Blacker, whose prime concern was with psycho-medical problems likely to concern people of all party persuasions. (shrink)

This Is A New Release Of The Original 1922 Edition.

This paper presents a theoretical elaboration of the ethical framework of classical capitalism as formulated by Adam Smith in reaction to the dominant mercantilism of his day. It is seen that Smith's project was profoundly ethical and designed to emancipate the consumer from a producer and state dominated economy. Over time, however, the various dysfunctions of a capitalist economy — e.g., concentration of wealth, market power — became manifest and the utilitarian ethical basis of the system eroded. Contemporary capitalism, dominated (...) as it is by large corporations, entrenched political interests and persistent social pathologies, bears little resemblance to the system which Smith envisioned would serve the common man. Most critiques of capitalism are launched from a Marxian-based perspective. We find, however, that by illustrating the wide gap between the reality of contemporary capitalism and the model of amoral political economy developed by Smith, the father of capitalism proves to be the most trenchant critic of the current order. (shrink)

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

This paper argues against the thesis of Professor Savan, that Spinoza's views about words and about the imagination are such that he could not consistently say, and indeed did not think, that philosophical truths can be expressed adequately in language. The evidence for this thesis is examined in detail, and it is argued that Spinoza should have distinguished between two types of imagination, corresponding roughly to Kant's transcendental and empirical imagination. Finally, it is suggested that the bulk of the argument (...) of the Ethics is conducted on the level of the ?second kind of knowledge?, reason, but that it also contains examples of the use of the first and third kinds of knowledge. (shrink)

First published in 2000, this translation of one of the great works of Western political thought is based on the assumption that when Plato chose the dialogue form for his writing, he intended these dialogues to sound like conversations - although conversations of a philosophical sort. In addition to a vivid, dignified and accurate rendition of Plato's text, the student and general reader will find many aids to comprehension in this volume: an introduction that assesses the cultural background to the (...) Republic, its place within political philosophy, and its general argument; succinct notes in the body of the text; an analytical summary of the work's content; a full glossary of proper names; a chronology of important events; and a guide to further reading. The result is an accomplished and accessible edition of this seminal work, suitable for philosophers and classicists as well as historians of political thought at all levels. (shrink)